Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats.
نویسندگان
چکیده
Co-administration of piperine, an alkaloid isolated from Piper nigrum L. enhanced bioavailability of beta lactam antibiotics, amoxycillin trihydrate and cefotaxime sodium significantly in rats. The improved bioavailability is reflected in various pharmacokinetic parameters viz. tmax, Cmax, t(1/2) and AUC, of these antibiotics. The increased bioavailability could be attributed to the effect of piperine on microsomal metabolising enzymes or enzymes system.
منابع مشابه
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ورودعنوان ژورنال:
- Indian journal of experimental biology
دوره 40 3 شماره
صفحات -
تاریخ انتشار 2002